The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP3, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009]
Alternative Names
DKFZP586K0919 DKFZp762A152 SENP3 sentrin/SUMO-specific protease 3 sentrin/SUMO-specific protease SENP3 smt3-specific isopeptidase 1 SUMO-1-specific protease 3 SUMO/sentrin specific peptidase 3 SUMO/sentrin specific protease 3 SUMO1/sentrin/SMT3 specific peptidase 3