This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. [provided by RefSeq, Nov 2015]
Alternative Names
bone proteoglycan II DCN dermatan sulfate proteoglycan-II (decorin) dermatan sulphate proteoglycans II Dermatan sulphate proteoglycans II (DSPG2) DSPG PG-S2 PG40 proteoglycan core protein Small leucine rich protein 1B small leucine-rich protein 1B