The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene. [provided by RefSeq, May 2022]
Alternative Names
hereditary hemochromatosis protein HLA-H HFE 1 high Fe HLA H MGC10379 MGC103790 MGC:150812 MHC class I-like protein HFE