| Product Name | Anti-TCL1A antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Polypeptide |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISA |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Symbol | TCL1A |
|---|---|
| Gene Synonyms | TCL1 |
| Gene Full Name | TCL1 family AKT coactivator A |
| Gene Summary | Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010] |
| Alternative Names | oncogene TCL-1 oncogene TCL1 protein p14 TCL1 T cell leukemia/lymphoma 1A T-cell lymphoma-1 T-cell lymphoma-1A TCL1A |
| Molecular Weight(MW) | 13kDa |
| Source | Rabbit |
| Cellular Localization | Cytoplasm;Nucleus;Microsome;Endoplasmic reticulum |
| SwissProt ID | P56279 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% PC300. |
