| Gene Symbol |
PKD2
|
| Gene Synonyms |
PC2, PKD4, Pc-2, APKD2, TRPP2 |
| Gene Full Name |
polycystin 2, transient receptor potential cation channel |
| Gene Summary |
This gene encodes a member of the polycystin protein family. The encoded protein is a multi-pass membrane protein that functions as a calcium permeable cation channel, and is involved in calcium transport and calcium signaling in renal epithelial cells. This protein interacts with polycystin 1, and they may be partners in a common signaling cascade involved in tubular morphogenesis. Mutations in this gene are associated with autosomal dominant polycystic kidney disease type 2. [provided by RefSeq, Mar 2011] |
| Alternative Names |
APKD2 Autosomal dominant polycystic kidney disease type II Autosomal dominant polycystic kidney disease type II protein MGC138466 MGC138468 PC 2 PC2 PKD 2 PKD2 PKD2_HUMAN PKD4 Polycystic kidney disease 2 (autosomal dominant) Polycystic kidney disease 2 Polycystic kidney disease 2 protein Polycystin 2 Polycystin 2 transient receptor potential cation channel Polycystin-2 Polycystin2 Polycystwin R48321 Transient receptor potential cation channel subfamily P member 2 TRPP2
|
| Molecular Weight(MW) |
110kDaa |
| Cellular Localization |
Cell projection>Cilium membrane>Multi-pass membrane protein. Endoplasmic reticulum membrane>Multi-pass membrane protein. Cell membrane>Multi-pass membrane protein. Basolateral cell membrane. Cytoplasmic vesicle membrane. Golgi apparatus. |