| Product Name | Anti-Phospho Chk2 (T68) Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide conjugated with KLH. |
| Modification | p-T68 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | CHEK2 |
|---|---|
| Gene Synonyms | CDS1 CHK2 LFS2 RAD53 TPDS4 hCds1 HuCds1 PP1425 |
| Gene Full Name | checkpoint kinase 2 |
| Gene Summary | In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene. |
| Alternative Names | CDS 1 Cds1 Cds1 homolog Checkpoint kinase 2 Checkpoint like protein CHK2 CHEK 2 Chek2 Chk 2 CHK2 checkpoint homolog (S. pombe) CHK2 checkpoint homolog CHK2_HUMAN hCds1 HuCds 1 LFS 2 LFS2 PP1425 RAD 53 RAD53 Rad53 homolog Serine/threonine protein kinase Chk2 Serine/threonine-protein kinase Chk2 |
| Molecular Weight(MW) | 61 kDa |
| Cellular Localization | Nucleus. |
| SwissProt ID | O96017 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide,40% Glycerol. |
