| Product Name | Anti-Phospho-DYRK1A/B (Tyr319/Tyr271) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide conjugated with KLH. |
| Modification | p-Tyr319/Tyr271 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | DYRK1A/DYRK1B |
|---|---|
| Gene Synonyms | MNB DYRK HP86 MNBH MRD7 DYRK1 MIRK AOMS3 |
| Gene Full Name | dual specificity tyrosine phosphorylation regulated kinase 1A/dual specificity tyrosine phosphorylation regulated kinase 1B |
| Gene Summary | This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq, Jul 2008] |
| Alternative Names | Dual specificity tyrosine phosphorylation regulated kinase Dual specificity tyrosine (Y) phosphorylation regulated kinase 1A Dual specificity tyrosine phosphorylation regulated kinase 1 Dual specificity tyrosine phosphorylation regulated kinase 1A Dual specificity tyrosine-phosphorylation-regulated kinase 1A Dual specificity YAK 1 related kinase Dual specificity YAK1 related kinase Dual specificity YAK1-related kinase DYR1A_HUMAN DYRK 1 DYRK 1A DYRK DYRK1 Dyrk1a DYRKA hMNB HP 86 HP86 Minibrain (Drosophila) homolog Minibrain homolog Minibrain Drosophila homolog of MNB MNB protein kinase Mnb protein kinase homolog hp86 MNB protein kinase Serine/threonine-specific MNB/DYRK protein kinase MNBH MRD7 OTTHUMP00000109090 OTTHUMP00000109091 OTTHUMP00000109094 OTTHUMP00000174799 Protein kinase minibrain homolog Serine/threonine kinase MNB AOMS3 Dual specificity tyrosine (Y) phosphorylation regulated kinase 1B Dual specificity tyrosine phosphorylation regulated kinase 1B Dual spec |
| Molecular Weight(MW) | 69 kDa |
| Cellular Localization | Nucleus. |
| SwissProt ID | Q13627 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide,40% Glycerol. |
