| Product Name | Anti-Phospho-NLRP3 (Ser194) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide conjugated with KLH. |
| Modification | p-Ser194 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | Nlrp3 |
|---|---|
| Gene Synonyms | FCU MWS FCAS Cias1 Mmig1 NALP3 Pypaf1 AII/AVP AGTAVPRL |
| Gene Full Name | NLR family, pyrin domain containing 3 |
| Gene Summary | Enables several functions, including ATP hydrolysis activity; phosphatidylinositol-4-phosphate binding activity; and signaling adaptor activity. Involved in several processes, including positive regulation of immune response; positive regulation of macromolecule biosynthetic process; and response to bacterium. Acts upstream of or within acute inflammatory response; defense response to virus; and regulation of inflammatory response. Located in interphase microtubule organizing center; mitochondrion; and nucleus. Part of NLRP3 inflammasome complex. Is active in membrane. Is expressed in central nervous system and retina. Used to study CINCA Syndrome; familial cold autoinflammatory syndrome 1; and metabolic dysfunction-associated steatotic liver disease. Human ortholog(s) of this gene implicated in CINCA Syndrome; Muckle-Wells syndrome; autosomal dominant nonsyndromic deafness 34; familial cold autoinflammatory syndrome 1; and urticaria. Orthologous to human NLRP3 (NLR family pyrin domain containing 3). [provided by Alliance of Genome Resources, Jul 2025] |
| Alternative Names | AGTAVPRL AII/AVP Angiotensin/vasopressin receptor AII/AVP like Angiotensin/vasopressin receptor AII/AVP-like C1orf7 Caterpiller protein 1.1 CIAS 1 CIAS1 CLR1.1 Cold autoinflammatory syndrome 1 Cold autoinflammatory syndrome 1 protein Cryopyrin Familial cold autoinflammatory syndrome FCAS FCU LRR and PYD domains-containing protein 3 Muckle-Wells syndrome MWS NACHT NACHT LRR and PYD containing protein 3 NALP 3 NALP3 NALP3_HUMAN NLR family pyrin domain containing 3 NLRP3 PYPAF 1 PYPAF1 PYRIN containing APAF1 like protein 1 PYRIN-containing APAF1-like protein 1 |
| Molecular Weight(MW) | 118 kDa |
| Cellular Localization | Cytoplasm,Cytoskeleton,Endoplasmic reticulum,Golgi apparatus,Inflammasome. |
| SwissProt ID | Q8R4B8 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide,40% Glycerol. |
