| Product Name | NLRP3/NALP3 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | NACHT-, LRR- and PYD-containing Protein 3; NLRP3; Cryopyrin; Cold Autoinflammatory Syndrome 1 Protein |
| Product description | The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor family, including NLRP3/NALP3, are critical components of the inflammasome that link danger-signals to caspase-1 activation. Defects in NLRP3 are the cause of familial cold autoinflammatory syndrome type 1 (FCAS1), Muckle-Wells syndrome (MWS) and of chronic infantile neurologic cutaneous and articular syndrome (CINCA). |
| Immunogen | Recombinant mouse NLRP3/NALP3 (pyrin domain/aa 1-93). |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG2b |
| Host Species | Mouse |
| Tested Applications | WB |
| Western Blot (see online protocol): (1ug/ml).: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | Nlrp3 |
|---|---|
| Alternative Names | NACHT- LRR- and PYD-containing Protein 3 NLRP3 Cryopyrin Cold Autoinflammatory Syndrome 1 Protein |
| Tissue Specificity | Recognizes mouse NLRP3/NALP3. |
| Application Notes | Western Blot (see online protocol): (1ug/ml).: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Stable for at least 1 year after receipt when stored at -20˚C. |
| Storage Buffer | Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. |
