| Product Name | Anti-Phospho-MDC1 (Thr4) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide conjugated with KLH. |
| Modification | p-Thr4 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | MDC1 |
|---|---|
| Gene Synonyms | NFBD1 |
| Gene Full Name | mediator of DNA damage checkpoint 1 |
| Gene Summary | The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq, Jul 2008] |
| Alternative Names | Homologue to Drosophila photoreceptor protein calphotin MDC 1 Mdc1 MDC1_HUMAN Mediation of DNA damage checkpoint 1 Mediator of DNA damage checkpoint 1 Mediator of DNA damage checkpoint protein 1 NFBD 1 NFBD1 Nuclear factor with BRCT domains 1 Nuclear Factor with BRCT Domains Protein 1 |
| Molecular Weight(MW) | 227 kDa |
| Cellular Localization | Chromosome,Nucleus. |
| SwissProt ID | Q14676 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide,40% Glycerol. |
