Western blot
0.2-1 ug/mlELISA Titer: 1:12500Positive Control: HepG2 cell lysate| Product Name | Rabbit anti-MDC1 polyclonal antibody - C-terminal region |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | DKFZp781A0122, KIAA0170, MGC166888, NFBD1 |
| Immunogen | The immunogen for anti-MDC1 antibody: synthetic peptide directed towards the C terminal of human MDC1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | DogGuinea PigHumanPig |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | MDC1 |
|---|---|
| Gene Synonyms | DKFZp781A0122 KIAA0170 MGC166888 NFBD1 |
| Gene Full Name | Mediator of DNA-damage checkpoint 1 |
| Gene Summary | The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. |
| Alternative Names | DKFZp781A0122 KIAA0170 MGC166888 NFBD1 |
| Molecular Weight(MW) | 227kDa |
| Sequence | 2089 amino acids |
Western blot
0.2-1 ug/mlELISA Titer: 1:12500Positive Control: HepG2 cell lysate| Application Notes | WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
