| Product Name | Anti-Phospho-TMS1/ASC (Ser195) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide conjugated with KLH |
| Modification | p-Ser195 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | PYCARD |
|---|---|
| Gene Synonyms | ASC TMS TMS1 CARD5 TMS-1 |
| Gene Full Name | PYD and CARD domain containing |
| Gene Summary | This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| Alternative Names | Apoptosis associated speck like protein containing a CARD Apoptosis-associated speck-like protein containing a CARD ASC ASC_HUMAN CARD 5 CARD5 Caspase recruitment domain containing protein 5 Caspase recruitment domain protein 5 Caspase recruitment domain-containing protein 5 hASC MGC10332 PYCARD PYD and CARD domain containing PYD and CARD domain containing protein PYD and CARD domain-containing protein Target of methylation induced silencing 1 Target of methylation-induced silencing 1 TMS 1 TMS TMS1 |
| Molecular Weight(MW) | 22 kDa |
| Cellular Localization | Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Inflammasome, Membrane, Mitochondrion, Nucleus |
| SwissProt ID | Q9ULZ3 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide,40% Glycerol. |
