| Gene Symbol |
MAP3K1
|
| Gene Synonyms |
MEKK MEKK1 SRXY6 MEKK 1 MAPKKK1 |
| Gene Full Name |
mitogen-activated protein kinase kinase kinase 1 |
| Gene Summary |
The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus. [provided by RefSeq, Mar 2012] |
| Alternative Names |
M3K1_HUMAN MAP3K1 MAPK/ERK kinase kinase 1 MAPKKK1 MEK kinase 1 MEKK 1 Mekk MEKK1 Mitogen activated protein kinase kinase kinase 1 Mitogen activated protein kinase kinase kinase 1 E3 ubiquitin protein ligase Mitogen-activated protein kinase kinase kinase 1 SRXY6
|
| Molecular Weight(MW) |
164 kDa |
| Cellular Localization |
Cytosol, Tight junction |