| Gene Symbol |
IRAK4
|
| Gene Synonyms |
IPD1 IMD67 REN64 IRAK-4 NY-REN-64 |
| Gene Full Name |
interleukin 1 receptor associated kinase 4 |
| Gene Summary |
This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011] |
| Alternative Names |
IL-1 receptor-associated kinase 4 Interleukin 1 receptor associated kinase 4 mutant form 1 Interleukin-1 receptor-associated kinase 4 Interleukin1 receptor associated kinase 4 IPD1 IRAK 4 IRAK-4 IRAK4 IRAK4 mutated form 1 IRAK4_HUMAN LOC 51135 NY REN 64 NY REN 64 antigen NY-REN-64 REN64 Renal carcinoma antigen NY-REN-64 |
| Molecular Weight(MW) |
52 kDa |
| Cellular Localization |
Cytoplasm. |