| Product Name | Anti-Phospho-MDM4 (Ser367) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide conjugated with KLH. |
| Modification | p-Ser367 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | MDM4 |
|---|---|
| Gene Synonyms | HDMX MDMX MRP1 BMFS6 |
| Gene Full Name | MDM4 regulator of p53 |
| Gene Summary | This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011] |
| Alternative Names | DKFZp781B1423 Double minute 4 Double minute 4 human homolog of p53 binding protein Double minute 4 protein HDMX MDM 4 Mdm2 like p53 binding protein Mdm2-like p53-binding protein MDM4 Mdm4 p53 binding protein homolog mouse Mdm4 protein MDM4 related protein 1 Mdm4 transformed 3T3 cell double minute 4 Mdm4 transformed 3T3 cell double minute 4 p53 binding protein Mdm4 transformed 3T3 cell double minute 4 p53 binding protein mouse MDM4_HUMAN Mdmx protein MGC132766 Mouse double minute 4 homolog Mouse double minute 4 human homolog of p53 binding protein MRP 1 MRP1 p53 binding protein p53 BINDING PROTEIN MDM4 p53-binding protein Mdm4 Protein Mdm4 Protein Mdmx |
| Molecular Weight(MW) | 55 kDa |
| Cellular Localization | Cytoplasm,Nucleus. |
| SwissProt ID | O15151 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide,40% Glycerol. |
