| Product Name | Anti-Phospho-APAF1 (Ser320) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide conjugated with KLH. |
| Modification | p-Ser320 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | APAF1 |
|---|---|
| Gene Synonyms | CED4 APAF-1 |
| Gene Full Name | apoptotic peptidase activating factor 1 |
| Gene Summary | This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
| Alternative Names | APAF 1 Apaf-1 APAF_HUMAN Apaf1 Apoptotic peptidase activating factor 1 Apoptotic protease activating factor 1 Apoptotic protease activating factor Apoptotic protease-activating factor 1 CED 4 CED4 KIAA0413 |
| Molecular Weight(MW) | 142 kDa |
| Cellular Localization | Cytoplasm. |
| SwissProt ID | O14727 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide,40% Glycerol. |
