Immunohistochemical analysis of paraffin-embedded breast cancer tissues using CXCR4 antibody with DAB staining.
Immunofluorescence analysis of A549 cells using CXCR4 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Source
Rabbit
Cellular Localization
Cytoplasm,Membrane
Application
IHC
Immunohistochemical analysis of paraffin-embedded breast cancer tissues using CXCR4 antibody with DAB staining.
ICC/IF
Immunofluorescence analysis of A549 cells using CXCR4 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application Notes
IHC:1:200-1:1000 ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage Instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05% sodium azide.
Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.
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