Bcl-2

Catalog Number：OM638970

  • Fig1: Western blot analysis of Jurkat cell lysate using anti-Bcl-2.

  • Fig2： Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-Bcl-2.

Product Profile

Product Name Bcl-2
Antibody Type Primary Antibodies
Product description 
The Bcl-2 family of proteins regulate apoptosis by controlling mitochondrial permeability and release of cytochrome c. Bcl-2 is an anti-apoptotic protein that resides in the outer mitochondrial wall and inhibits release of cytochrome c (1). Over-expression of Bcl-2 has been shown to promote cell survival by suppressing apoptosis. It has been documented that bcl-2 becomes deregulated in tumor cells as a result of translocation into the immunoglobulin heavy-chain locus and is therefore activated in B cell malignancies (2). It has also been shown that post-translational modification of Bcl-2, phosphorylation at serine 70, may be required to render its full and/or enhanced anti-apoptotic effect (3, 4).
Immunogen 
peptide

Key Feature

Clonality Polyclonal
Isotype IgG
Host Species Rabbit
Tested Applications

WBICCIHCFCIP
WB:1:1,000
ICC:1:200
IHC:1:100-200
IP:1:50
FC:1:100
Species Reactivity

HumanMouse
Concentration 1 mg/mL.

Target Information

Alternative Names
Apoptosis regulator Bcl 2 antibody Apoptosis regulator Bcl-2 antibody Apoptosis regulator Bcl2 antibody AW986256 antibody B cell CLL/lymphoma 2 antibody B cell leukemia/lymphoma 2 antibody Bcl-2 antibody Bcl2 antibody BCL2_HUMAN antibody C430015F12Rik antibody D630044D05Rik antibody D830018M01Rik antibody Leukemia/lymphoma
B-cell
2 antibody Oncogene B-cell leukemia 2 antibody PPP1R50 antibody Protein phosphatase 1
regulatory subunit 50 antibody
Molecular Weight(MW) 26kDa
Cellular Localization Nucleus membrane, Mitochondrion outer membrane Endoplasmic reticulum membrane

Database Links

SwissProt ID P10415

Application

  • Application

    Fig1: Western blot analysis of Jurkat cell lysate using anti-Bcl-2.

  • Application

    Fig2： Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-Bcl-2.

Positive Control Jurkat, human tonsil tissue
Application Notes
WB:1:1,000
ICC:1:200
IHC:1:100-200
IP:1:50
FC:1:100

Additional Information

Form Liquid
Storage Instructions Store at -20 ℃. Stable for 12 months from date of receipt
Storage Buffer 1*TBS (pH7.4), 0.5%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.

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  • Catalog Number: OM638970
  • Price: $336.00
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  • Lead time: 4~6 Week

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