All products Antibodies CDK5R1 Antibody

CDK5R1 Antibody

Catalog Number：OM275153

  • Western blot analysis in A2058 cell line lysates (35ug/lane).

  • Formalin-fixed and paraffin-embedded human brain tissue reacted with CDK5R1(p35) Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.

Product Profile

Product Name CDK5R1 Antibody
Antibody Type Primary Antibodies
Product description 
p35 is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.1) Lin,S., FEBS Lett. 582 (8), 1197-1202 (2008)
Immunogen 
This CDK5R1(p35) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 272-301 amino acids from the C-terminal region of human CDK5R1(p35).

Key Feature

Clonality Polyclonal
Isotype Ig
Host Species Rabbit
Tested Applications

IHC-PWB
For IHC-P starting dilution is: 1:10~50 For WB starting dilution is: 1:1000:
Species Reactivity

Human
Concentration 1 mg/ml
Purification Affinity purified

Target Information

Gene Symbol CDK5R1
Alternative Names
Cyclin-dependent kinase 5 activator 1
CDK5 activator 1
Cyclin-dependent kinase 5 regulatory subunit 1
TPKII regulatory subunit
Cyclin-dependent kinase 5 activator 1
p35
p35
Cyclin-dependent kinase 5 activator 1
p25
p25
Tau protein kinase II 23 kD
Molecular Weight(MW) 34 kDa
Sequence Similarities Predicted species reactivity based on immunogen sequence: Bovine

Database Links

Entrez Gene 8851
Protein Accession Q15078

Application

  • Application

    Western blot analysis in A2058 cell line lysates (35ug/lane).

  • Application

    Formalin-fixed and paraffin-embedded human brain tissue reacted with CDK5R1(p35) Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.

Application Notes
For IHC-P starting dilution is: 1:10~50 For WB starting dilution is: 1:1000:

Additional Information

Form Liquid
Storage Instructions Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Storage Buffer Supplied in PBS with 0.09% (W/V) sodium azide.
Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.

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  • Catalog Number: OM275153
  • Price: $336.00
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