IL-8RB Antibody (K-19) PE

Product Profile

Product Name	IL-8RB Antibody (K-19) PE
Antibody Type	Primary Antibodies
Modification Notes	IL-8 has been shown to function as a potent neutrophil chemostatic and activating peptide and is an important mediator of inflammatory diseases. Two distinct human IL-8 receptors, designated IL-8RA and IL-8RB, have been characterized. Both are expressed at a high level on neutrophils, and to a lesser extent on monocytes and myeloid cell lines. In addition, the IL-8RA subunit is expressed in T cells such as the Jurkat cell line. Both IL-8Rs are members of the seven transmembrane domain rhodopsin superfamily of receptors and as such, couple G proteins for signal transduction. The two receptors share 77% amino acid identity. IL-8RA exhibits high affinity binding for IL-8 and low affinity MGSA binding, whereas IL-8RB has high affinity binding for both IL-8 and MGSA.

Key Feature

Clonality	Polyclonal
Isotype	IgG
Host Species	Rabbit
Tested Applications	WBIPIFFCELISA
	recommended for detection of IL-8RB of mouse, rat and, to a lesser extent, human origin by WB, IP, IF, FCM and ELISA:
Species Reactivity	HumanMouseRat
Concentration	1mg/ml
Purification	Affinity purified

Target Information

Alternative Names	epitope mapping at the C-terminus of IL-8RB of mouse origin
Tissue Specificity	epitope mapping at the C-terminus of IL-8RB of mouse origin

Database Links

Entrez Gene	3579

Application

Application Notes	recommended for detection of IL-8RB of mouse, rat and, to a lesser extent, human origin by WB, IP, IF, FCM and ELISA:

Additional Information

Form	Liquid
Storage Instructions	For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer	phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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• Data sheet for OM164227