NCK1 Antibody (N-term)

Product Profile

Product Name	NCK1 Antibody (N-term)
Antibody Type	Primary Antibodies

Key Feature

Clonality	Polyclonal
Isotype	Ig
Host Species	Rabbit
Tested Applications	WBFC
	WB~~1:100~500 FC~~1:10~50:
Species Reactivity	Human
Concentration	1 mg/ml
Purification

Target Information

Gene Synonyms	NCK
Alternative Names	NCK1 NCK Cytoplasmic protein NCK1 NCK adaptor protein 1 SH2/SH3 adaptor protein NCK-alpha
Molecular Weight(MW)	42864 Da
Function	Adapter protein which associates with tyrosine- phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling
Tissue Specificity	This NCK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 9~38 amino acids from the N-terminal region of human NCK1.
Cellular Localization	Cytoplasm. Endoplasmic reticulum. Nucleus. Note=Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Import into the nucleus requires the interaction with SOCS7. Predominantly nuclear following genotoxic stresses, such as UV irradiation, hydroxyurea or mitomycin C treatments

Database Links

Entrez Gene	4690

Application

Application Notes	WB~~1:100~500 FC~~1:10~50:

Additional Information

Form	Liquid
Storage Instructions	For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

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• Data sheet for OM215056