NDN Antibody (N-term)

Product Profile

Product Name	NDN Antibody (N-term)
Antibody Type	Primary Antibodies

Key Feature

Clonality	Polyclonal
Isotype	Ig
Host Species	Rabbit
Tested Applications	WBFC
	WB~~1:100~500 FC~~1:10~50:
Species Reactivity	Human
Concentration	1 mg/ml
Purification

Target Information

Alternative Names	NDN Necdin
Molecular Weight(MW)	36086 Da
Function	Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle- promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Functions also as transcription factor and binds directly to specific guanosine-rich DNA sequences (By similarity)
Tissue Specificity	Almost ubiquitous. Detected in fetal brain, lung, liver and kidney; in adult heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine and colon. Not detected in peripheral blood leukocytes. In brain, restricted to post- mitotic neurons
Cellular Localization	Perikaryon. Nucleus. Note=Neural perikarya, translocates to the nucleus of postmitotic neurons and interacts with the nuclear matrix

Database Links

Entrez Gene	4692
Nucleotide Accession	NP_002478.1

Application

Application Notes	WB~~1:100~500 FC~~1:10~50:

Additional Information

Form	Liquid
Storage Instructions	For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

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• Data sheet for OM215090