All products Antibodies Rabbit anti-DFFA polyclonal antibody - N-terminal region

Rabbit anti-DFFA polyclonal antibody - N-terminal region

Catalog Number：OM105172

  • 5.0ug/ml
    ELISA Titer: 1:312500
    Positive Control: Jurkat cell lysate

Product Profile

Product Name Rabbit anti-DFFA polyclonal antibody - N-terminal region
Antibody Type Primary Antibodies
Immunogen 
The immunogen for anti-DFFA antibody: synthetic peptide directed towards the N terminal of human DFFA

Key Feature

Clonality Polyclonal
Isotype IgG
Host Species Rabbit
Tested Applications

WB
WB:1:500~1:2000
Notes:Optimal dilutions/concentrations should be determined by the researcher.
Species Reactivity

BovineDogGuinea PigHumanMouseRat
Concentration 1 mg/ml
Purification Protein A

Target Information

Gene Symbol DFFA
Gene Synonyms
DFF-45
DFF1
Ion ChannelAD
ICAD
Gene Full Name DNA fragmentation factor, 45kDa, alpha polypeptide
Gene Summary
Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis.Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Alternative Names
DFF-45
DFF1
Ion ChannelAD
ICAD
Molecular Weight(MW) 37kDa
Sequence 331 amino acids

Database Links

Entrez Gene 1676
SwissProt ID O00273
Protein Accession NP_004392

Application

  • Western blot

    5.0ug/ml
    ELISA Titer: 1:312500
    Positive Control: Jurkat cell lysate

Application Notes
WB:1:500~1:2000
Notes:Optimal dilutions/concentrations should be determined by the researcher.

Additional Information

Form Liquid
Storage Instructions Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles
Storage Buffer phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.

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  • Catalog Number: OM105172
  • Price: $336.00
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  • Lead time: 2~3 Week

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