All products Antibodies Rabbit anti-RELA polyclonal antibody - middle region

Rabbit anti-RELA polyclonal antibody - middle region

Catalog Number：OM105176

  • 0.2-1 ug/ml
    ELISA Titer: 1:312500
    Positive Control: Transfected 293T

Product Profile

Product Name Rabbit anti-RELA polyclonal antibody - middle region
Antibody Type Primary Antibodies
Immunogen 
The immunogen for anti-RELA antibody: synthetic peptide directed towards the middle region of human RELA

Key Feature

Clonality Polyclonal
Isotype IgG
Host Species Rabbit
Tested Applications

WB
WB:1:500~1:2000
Notes:Optimal dilutions/concentrations should be determined by the researcher.
Species Reactivity

Human
Concentration 1 mg/ml
Purification Affinity purified

Target Information

Gene Symbol RELA
Gene Synonyms
MGC131774
NFKB3
p65
Gene Full Name V-rel reticuloendotheliosis viral oncogene homolog A (avian)
Gene Summary
p65 is a subunit of the nuclear factor kappa-B, a second messenger, which activates the transcription of a number of genes in multiple tissues. The inhibitory effect of I-kappa-B upon NF-kappa-B in the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA, or RELB (MIM 604758) to form the NFKB complex. The p50 (NFKB1)/p65 (RELA) heterodimer is the most abundant form of NFKB. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008 or NFKBIB, MIM 604495), which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NFKB complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-1760 M62399.1 8-1767
Alternative Names
MGC131774
NFKB3
p65
Molecular Weight(MW) 60kDa
Sequence 551 amino acids

Database Links

Entrez Gene 5970
SwissProt ID Q04206
Protein Accession NP_068810

Application

  • Western blot

    0.2-1 ug/ml
    ELISA Titer: 1:312500
    Positive Control: Transfected 293T

Application Notes
WB:1:500~1:2000
Notes:Optimal dilutions/concentrations should be determined by the researcher.

Additional Information

Form Liquid
Storage Instructions Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles
Storage Buffer phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.

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  • Catalog Number: OM105176
  • Price: $336.00
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  • Lead time: 2~3 Week

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