Immunohistochemistry
Immunohistochemistry with Prostate tissue at an antibody concentration of 5ug/ml using anti-TRPM8 antibodyWestern blot
0.2-1 ug/ml| Product Name | TRPM8 antibody - N-terminal region |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | The immunogen for anti-TRPM8 antibody: synthetic peptide directed towards the N terminal of human TRPM8 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB,IHC |
| Species Reactivity | Bovine,Dog,Guinea Pig,Horse,Human,Mouse,Pig,Rabbit,Rat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | TRPM8 |
|---|---|
| Gene Synonyms | LTRPC6 MGC2849 TRPP8 |
| Gene Full Name | Transient receptor potential cation channel, subfamily M, member 8 |
| Gene Summary | TRPM8 is the receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. TRPM8 is activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. TRPM8 is involved in menthol sensation. TRPM8 is permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. TRPM8 was activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. |
| Alternative Names | LTRPC6 MGC2849 TRPP8 |
| Molecular Weight(MW) | 128kDa |
| Sequence | 1104 amino acids |
Immunohistochemistry
Immunohistochemistry with Prostate tissue at an antibody concentration of 5ug/ml using anti-TRPM8 antibody
Western blot
0.2-1 ug/ml| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
