Western blot
0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: THP-1 cell lysate| Product Name | Rabbit anti-MAP3K7IP1 polyclonal antibody - N-terminal region |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | 3'-Tab1, MGC57664, TAB1, MAP3K7IP1 |
| Immunogen | The immunogen for anti-MAP3K7IP1 antibody: synthetic peptide directed towards the N terminal of human MAP3K7IP1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | MAP3K7IP1 |
|---|---|
| Gene Synonyms | 3' -Tab1 MGC57664 TAB1 MAP3K7IP1 |
| Gene Full Name | TGF-beta activated kinase 1/MAP3K7 binding protein 1 |
| Gene Summary | The specific function of the protein remains unknown.The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. |
| Alternative Names | 3'-Tab1 MGC57664 TAB1 MAP3K7IP1 |
| Molecular Weight(MW) | 50kDa |
| Sequence | 462 amino acids |
Western blot
0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: THP-1 cell lysate| Application Notes | WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Data sheet for OM115180