| Product Name | Anti-Phospho-TAB1 (Tyr481) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide conjugated with KLH. |
| Modification | p-Tyr481 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | TAB1 |
|---|---|
| Gene Synonyms | 3'-Tab1 MAP3K7IP1 |
| Gene Full Name | TGF-beta activated kinase 1 (MAP3K7) binding protein 1 |
| Gene Summary | The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] |
| Alternative Names | 2310012M03Rik 3'-Tab1 MAP3K7IP 1 MAP3K7IP1 MGC57664 Mitogen activated protein kinase kinase kinase 7 interacting protein 1 Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 TAB 1 TAB1 TAB1_HUMAN TAK1 binding protein 1 TAK1-binding protein 1 TGF beta activated kinase 1 binding protein 1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 TGF-beta-activated kinase 1-binding protein 1 Transforming growth factor beta activated kinase binding protein 1 |
| Molecular Weight(MW) | 55 kDa |
| Cellular Localization | Cytoplasm,Endoplasmic reticulum,Membrane. |
| SwissProt ID | Q15750 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide,40% Glycerol. |
