Immunohistochemistry
Immunohistochemistry with Brain, cortex tissue at an antibody concentration of 5ug/ml using anti-HEXA antibodyWestern blot
1 ug/mlPositive Control: Fetal kidney lysate| Product Name | Rabbit anti-HEXA polyclonal antibody - C-terminal region |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | MGC99608, TSD |
| Immunogen | The immunogen for anti-HEXA antibody: synthetic peptide directed towards the C terminal of human HEXA |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:500~1:2000 IHC:1:50~1:200 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | BovineDogGuinea PigHorseHumanMousePigRabbitRatSheep |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | HEXA |
|---|---|
| Gene Synonyms | MGC99608 TSD |
| Gene Full Name | Hexosaminidase A (alpha polypeptide) |
| Gene Summary | This gene encodes the alpha subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Alpha subunit gene mutations lead to Tay-Sachs disease (GM2-gangliosidosis type I). |
| Alternative Names | MGC99608 TSD |
| Molecular Weight(MW) | 48kDa |
| Sequence | 529 amino acids |
Immunohistochemistry
Immunohistochemistry with Brain, cortex tissue at an antibody concentration of 5ug/ml using anti-HEXA antibody
Western blot
1 ug/mlPositive Control: Fetal kidney lysate| Application Notes | WB:1:500~1:2000 IHC:1:50~1:200 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
