Application
A. Immunohistochemical analysis of paraffin-embedded cervical carcinoma using anti-Mcl-1 RabMAb (Cat. #AJ1463a).Application
B. Immunohistochemical analysis of paraffin-embedded human tonsils using anti-Mcl-1 RabMAb (Cat. #AJ1463a).Application
C. Western blot analysis on A431 cell lysate using anti-Mcl-1 RabMAb (Cat. #AJ1463a), dilution 1:1,000.| Product Name | Mcl-1 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | MCL1, BCL2L3, Induced myeloid leukemia cell differentiation protein Mcl-1, Bcl-2-related protein EAT/mcl1;mcl1/EAT;Bcl-2-like protein 3 |
| Clonality | Monoclonal |
|---|---|
| Clone Number | Y37 |
| Host Species | Rabbit |
| Tested Applications | IHCWB |
| IHC:1:50 WB |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | BCL2L3 |
|---|---|
| Alternative Names | MCL1 BCL2L3 Induced myeloid leukemia cell differentiation protein Mcl-1 Bcl-2-related protein EAT/mcl1 mcl1/EAT Bcl-2-like protein 3 |
| Molecular Weight(MW) | 37337 Da |
| Function | Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis Isoform 2 promotes apoptosis |
| Tissue Specificity | A synthetic peptide corresponding to residues of human Mcl-1 was used as immunogen. The antibody does not cross-react with other Bcl-2 family members. |
| Cellular Localization | Membrane; Single-pass membrane protein (Potential). Cytoplasm. Mitochondrion. Nucleus, nucleoplasm Note=Cytoplasmic, associated with mitochondria |
| Entrez Gene | 4170 |
|---|
Application
A. Immunohistochemical analysis of paraffin-embedded cervical carcinoma using anti-Mcl-1 RabMAb (Cat. #AJ1463a).
Application
B. Immunohistochemical analysis of paraffin-embedded human tonsils using anti-Mcl-1 RabMAb (Cat. #AJ1463a).
Application
C. Western blot analysis on A431 cell lysate using anti-Mcl-1 RabMAb (Cat. #AJ1463a), dilution 1:1,000.| Application Notes | IHC:1:50 WB |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
