Application
MCL1 Antibody (Center) western blot analysis in Y79 cell line lysates (35ug/lane).This demonstrates the MCL1 antibody detected the MCL1 protein (arrow).Application
MCL1 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of MCL1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.| Product Name | MCL1 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | MCL1; BCL2L3; Induced myeloid leukemia cell differentiation protein Mcl-1; Bcl-2-like protein 3; Bcl-2-related protein EAT/mcl1; mcl1/EAT |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | BCL2L3 |
|---|---|
| Alternative Names | MCL1 BCL2L3 Induced myeloid leukemia cell differentiation protein Mcl-1 Bcl-2-like protein 3 Bcl-2-related protein EAT/mcl1 mcl1/EAT |
| Molecular Weight(MW) | 37337 Da |
| Function | Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis Isoform 2 promotes apoptosis |
| Tissue Specificity | This MCL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 216-245 amino acids from the Central region of human MCL1. |
| Cellular Localization | Membrane; Single-pass membrane protein (Potential). Cytoplasm. Mitochondrion. Nucleus, nucleoplasm Note=Cytoplasmic, associated with mitochondria |
| Entrez Gene | 4170 |
|---|---|
| Nucleotide Accession | NP_877495.1 NP_068779.1 |
Application
MCL1 Antibody (Center) western blot analysis in Y79 cell line lysates (35ug/lane).This demonstrates the MCL1 antibody detected the MCL1 protein (arrow).
Application
MCL1 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of MCL1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
