Application
Figure 1: Western blot analysis using anti-PR monoclonal antiobdy against PR recombinant protein(1).Application
Figure 2: Immunohistochemical analysis of paraffin-embedded human infiltrating ductal carcinoma tissue(left) and simple carcinoma of breast cancer tissue(right), showing nuclear localization using anti-PR antibody with DAB staining.| Product Name | PR Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | PR; NR3C3; PGR |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | 2F12B4,2F12H2 |
| Host Species | Mouse |
| Tested Applications | WBIHC |
| WB:1:500 - 2000. IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | NR3C3 |
|---|---|
| Alternative Names | PR NR3C3 PGR |
| Molecular Weight(MW) | 98981 Da |
| Function | The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation |
| Tissue Specificity | Purified recombinant fragment of PR expressed in E. Coli. |
| Cellular Localization | Nucleus. Cytoplasm. Note=Nucleoplasmic shuttling is both homone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases |
| Entrez Gene | 5241 |
|---|---|
| Nucleotide Accession | NP_000917.3 |
Application
Figure 1: Western blot analysis using anti-PR monoclonal antiobdy against PR recombinant protein(1).
Application
Figure 2: Immunohistochemical analysis of paraffin-embedded human infiltrating ductal carcinoma tissue(left) and simple carcinoma of breast cancer tissue(right), showing nuclear localization using anti-PR antibody with DAB staining.| Application Notes | WB:1:500 - 2000. IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified recombinant fragment of PR expressed in E. Coli. |
