Application
BBC3 Antibody (Center) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the BBC3 antibody detected the BBC3 protein (arrow).Application
BBC3 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human cervix tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of BBC3 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.| Product Name | BBC3 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | PUMA |
|---|---|
| Alternative Names | BBC3 PUMA Bcl-2-binding component 3 JFY-1 p53 up-regulated modulator of apoptosis |
| Molecular Weight(MW) | 20532 Da |
| Function | Essential mediator of p53/TP53-dependent and p53/TP53- independent apoptosis. Regulates ER stress-induced neuronal apoptosis (By similarity) |
| Tissue Specificity | Ubiquitously expressed. |
| Cellular Localization | Mitochondrion. Note=Localized to the mitochondria in order to induce cytochrome c release |
| Entrez Gene | 27113 |
|---|---|
| Nucleotide Accession | NP_055232.1 NP_001120714.1 NP_001120713.1 |
Application
BBC3 Antibody (Center) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the BBC3 antibody detected the BBC3 protein (arrow).
Application
BBC3 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human cervix tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of BBC3 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
