MME EPN Neprilysin Enkephalinase Atriopeptidase Common acute lymphocytic leukemia antigen
Molecular Weight(MW)
85514 Da
Function
Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV- inducible elastase activity toward skin preelastic and elastic fibers
Tissue Specificity
A synthetic peptide corresponding to residues on human CD10 was used as an immunogen.
Cellular Localization
Cell membrane; Single-pass type II membrane protein