Application
Dicer1 Antibody (Cat. #AM1970a) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the Dicer1 antibody detected the Dicer1 protein (arrow).| Product Name | Dicer1 Antibody (Ascites) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | DICER1; DICER; HERNA; KIAA0928; Endoribonuclease Dicer; Helicase with RNase motif |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | 336CT7.4.2 |
| Host Species | Mouse |
| Tested Applications | WB |
| WB:1:500~2000 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | DICER HERNA KIAA0928 |
|---|---|
| Alternative Names | DICER1 DICER HERNA KIAA0928 Endoribonuclease Dicer Helicase with RNase motif |
| Molecular Weight(MW) | 218682 Da |
| Function | Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre- miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2 EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. Also cleaves double-stranded RNA to produce short interfering RNAs (siRNAs) which target the selective destruction of complementary RNAs |
| Tissue Specificity | This DICER1 monoclonal antibody is generated from mouse immunized with DICER1 recombinant protein. |
| Cellular Localization | Cytoplasm. |
| Entrez Gene | 23405 |
|---|---|
| Nucleotide Accession | NP_803187.1 NP_085124.2 |
Application
Dicer1 Antibody (Cat. #AM1970a) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the Dicer1 antibody detected the Dicer1 protein (arrow).| Application Notes | WB:1:500~2000 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. |
