Application
Figure 1: Western blot analysis using anti-FRK mAb against K562 cell lysate (1).| Product Name | FRK Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | GTK; RAK; PTK5 |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | 40 |
| Host Species | Mouse |
| Tested Applications | WB |
| WB:1:500 - 2000. |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | PTK5 RAK |
|---|---|
| Alternative Names | GTK RAK PTK5 |
| Molecular Weight(MW) | 58254 Da |
| Function | Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor |
| Tissue Specificity | Predominantly expressed in epithelial derived cell lines and tissues, especially normal liver, kidney, breast and colon |
| Cellular Localization | Cytoplasm. Nucleus. Note=Predominantly found in the nucleus, with a small fraction found in the cell periphery |
| Entrez Gene | 2444 |
|---|---|
| Nucleotide Accession | NP_002022.1 |
Application
Figure 1: Western blot analysis using anti-FRK mAb against K562 cell lysate (1).| Application Notes | WB:1:500 - 2000. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified recombinant fragment of human FRK expressed in E. Coli. |
