Application
Immunohistochemistry: 5HT1B Receptor Antibody [ - Staining of vascular smooth muscle| Product Name | 5-HT1B receptor antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal antibody to Serotonin receptor 1B5-HT1B (5-HT1D beta), a Serotonin Receptor, inhibits neurotransmitter release from neuronal terminals. Knockout mutant mice lacking this receptor exhibit decreased anxiety, increased aggression, and augmented alcohol and cocaine consumption compared to controls. 5-HT1B receptors have been found to control areas of the human brain involved in migraine pain, bipolar disorder, and obsessive compulsive disorder. The 5-HT1B receptor has been reported to be expressed in a variety of neurons predominantly in the central nervous system. It has been suggested that Human 5-HT1B receptors are located somatodendritically on GABAergic and peptidergic caudate-putamen neurons which project to the substantia nigra and globus pallidus, where these receptors are presynaptic. 5-HT1B expression has also been seen in heart, blood vessels, and eye. |
| Immunogen | Synthetic peptide [KLH conjugated] made to the 3rd cytoplasmic loop |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHC-P |
| Optimal concentration should be determined experimentally by the end user.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Purification | Affinity purified |
| Gene Synonyms | 3351 HTR1D2 5HT HTR1DB HTR1B 5-HT1B S12 5HT1DB 5-HT1DB 5HT1B 5 HT1B receptor 5HT1B receptor 5 HT1B 5 HT1DB |
|---|---|
| Target | Serotonin receptor 1B |
| Tissue Specificity | 5-HT1B Receptor |
| Cellular Localization | Cell Membrane |
Application
Immunohistochemistry: 5HT1B Receptor Antibody [ - Staining of vascular smooth muscle| Application Notes | Optimal concentration should be determined experimentally by the end user.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Storage Buffer | PBS |
