Rabbit Polyclonal antibody to ABCG2The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, the human protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. This protein likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. [provided by RefSeq, Jul 2008]
Immunogen
A synthetic peptide corresponding to a sequence in the middle region of mouse ABCG2, different from the related rat sequence by one amino acid.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WB
WB:1:250~1:1000 Notes:Optimal dilutions/concentrations should be determined by the researcher.
Species Reactivity
MouseRat
Concentration
0.5mg/ml
Purification
Affinity purified
Target Information
Gene Synonyms
BCRP Bcrp1 MXR ABC15 ABCP Abcg2 AI428558 MXR1 ATP-binding cassette sub-family G (WHITE) member 2
Target
ABCG2
Application
Application
Lane 1: Rat Liver Tissue Lysate Lane 2: Rat Spleen Tissue Lysate Lane 3: Rat Kidney Tissue Lysate Lane 4: Mouse Spleen Tissue Lysate
Application Notes
WB:1:250~1:1000 Notes:Optimal dilutions/concentrations should be determined by the researcher.
Additional Information
Form
Liquid
Storage Instructions
Keep as concentrated solution. Aliquot and store at -20ºC. Avoid multiple freeze-thaw cycles.