| Product Name | Activin Receptor Type IIB antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal antibody [6L11] to Activin Receptor Type IIBActivins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for t |
| Immunogen | Recombinant Activin RIIB extra cellular domain |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | 6L11 |
| Host Species | Mouse |
| Tested Applications | IHCWB |
| WB(1:100-1000)|IHC(1:50-100): |
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| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | ACTRIIB ACVR2B HTX4 activin A receptor type IIB ActR-IIB |
|---|---|
| Target | Activin RIIB |
| Tissue Specificity | This antibody was selected for its ability to detect human Activin RIIB. Weak cross reactivity was found to hActivin RIIA |
| Application Notes | WB(1:100-1000)|IHC(1:50-100): |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | PBS |
