| Product Name | ATR antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal antibody to ATRThe protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist. [provided by RefSeq, Jul 2008] |
| Immunogen | Human ATR peptide, amino acids 2381-2644 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| Western Blotting: Max Dilution 1/2000 Optimal dilution / concentration should be determined by the end user.: |
|
| Species Reactivity | HumanMouseHamster |
| Concentration | 1mg/ml |
| Purification | Serum |
| Gene Synonyms | SCKL1 FRP1 ataxia telangiectasia and Rad3 related FCTCS SCKL MEC1 |
|---|---|
| Target | ATR |
| Tissue Specificity | This antibody recognizes the ATR (Ataxia telangiectasia and rad 3 related) protein, a 300kD protein kinase reported to have a role in recognising and responding to DNA strand interruptions during meiosis.this antibody cross-reacts with the related DNA-Pkc |
| Application Notes | Western Blotting: Max Dilution 1/2000 Optimal dilution / concentration should be determined by the end user.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4°C for one month or at -20°C for longer. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. |
| Storage Buffer | 0.09%Sodium Azide |
