Rabbit Polyclonal antibody to BAFF ReceptorB cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival. [provided by RefSeq, Jul 2008]
Immunogen
Synthetic peptide corresponding to a region within the C-terminus of human CD268.
WB analysis of human (H), mouse (M) and rat (R) spleen tissue lysates using BAFF Receptor antibody
Application
IHC analysis of human tonsil tissue using BAFF Receptor antibody.
Application Notes
WB: 2 - 5 ug/ml:
Additional Information
Form
Liquid
Storage Instructions
Store at +4oC or at -20oC if preferred. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody.