| Product Name | BRCA1 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse polyclonal antiserum to BRCA1BRCA1, a 220kDa nuclear phosphoprotein, is recognized by this antibody. Mutations in the BRCA1 tumor suppressor gene greatly increase the risk of breast cancer. In a high proportion of breast and ovarian cancer cell lines, BRCA1 aberrantly mislocates to the cytoplasm. Recent studies suggest BRCA1 also has a role in DNA double strand break repair because of its association with Rad51. |
| Immunogen | A synthetic peptide from the human BRCA1 protein corresponding to carboxyl terminal amino acids 1848-1863 (QELDTYLIPQIPHSHY). |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Mouse |
| Tested Applications | IHC,IP,WB |
| For IP: Use at an assay dependent dilution. For WB: Use at an assay dependent dilution. Predicted molecular weight: 208 kDa. Optimal dilutions/concentrations should be determined by the researcher. | |
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | 113705, RNF53, BRCA1, BRCAI, 672, PSCP, BRCC1, P38398, IRIS |
|---|---|
| Target | BRCA1 |
| Cellular Localization | Nuclear |
Application
| Application Notes | For IP: Use at an assay dependent dilution. For WB: Use at an assay dependent dilution. Predicted molecular weight: 208 kDa. Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| Storage Buffer | Anti-serum. |
