| Product Name | Calpain 2 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal [1E8] to Calpain 2Proteases influence intracellular signaling pathways and regulate cytoskeleton organization. It was previously described that novel autoantibodies to calpastatin (endogenous inhibitor for calpain) were detected in patients with rheumatoid arthritis (RA) and other disorders. Since calpain is thought to mediate inflammatory process and cartilage destruction a screening of anti-calpain antibodies in human patient sera is recommended. |
| Immunogen | Bovine cardiac Calpain 2. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | 1E8 |
| Host Species | Mouse |
| Tested Applications | ELISAICC/IFWB |
| Western blot: 1 μg/ml. Immunofluorescence: use the antibody after 2% paraformaldehyde fixation in a concentration of 0.5 μg/ml.: |
|
| Species Reactivity | HumanBovine |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | 114230 Calpain2 mCANP CAPN2 P17655 824 CANPml CANPL2 Calpain 2 |
|---|---|
| Target | Calpain 2 |
| Tissue Specificity | Recognises a linear epitope of the 80 kDa (large) subunit of bovine m-calpain |
| Cellular Localization | Cytoplasmic. Translocates to the plasma membrane upon Ca 2+ binding. |
| Light Chain Type | kappa |
| Application Notes | Western blot: 1 μg/ml. Immunofluorescence: use the antibody after 2% paraformaldehyde fixation in a concentration of 0.5 μg/ml.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Upon receipt - Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| Storage Buffer | Preservative: 0.02% Sodium Azide; Constituents: PBS |
