| Product Name | CCR5 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal antibody [6H20] to CCR5This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gen |
| Immunogen | Human CCR5 transfected 293 cells |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG2 |
| Clone Number | 6H20 |
| Host Species | Mouse |
| Tested Applications | IHCWB |
| WB(1:400-1600)|IHC(50:200): |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | chemokine (C-C motif) receptor 5 (gene/pseudogene) CD195 CKR5 CCCKR5 CC-CKR-5 CMKBR5 IDDM22 CKR-5 CCR-5 |
|---|---|
| Target | CCR5 |
| Tissue Specificity | This antibody was selected for its ability to detect human CCR5, not other CCRs |
| Application Notes | WB(1:400-1600)|IHC(50:200): |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | PBS |
