| Product Name | CD11a antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Monoclonal Antibody to CD11a (Human) Azide FreeITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] |
| Immunogen | Human peripheral blood lymphocytes |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | MEM-83 |
| Host Species | Mouse |
| Tested Applications | BlockingFACS |
| FuncS: The antibody induces high-affinity conformation of LFA-1.: |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Purification | Affinity purified |
| Gene Synonyms | 153370 LFA1 CD11a 3683 LFA1A LFA-1 ITGAL P20701 LFA 1 |
|---|---|
| Target | CD11a |
| Tissue Specificity | The antibody recognizes an unique epitope on CD11a antigen (LFA-1 alpha chain) implicated in activation of LFA-1 complex. |
| Application Notes | FuncS: The antibody induces high-affinity conformation of LFA-1.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Store at 4°C short term. For extended storage aliquot and store at -20°C or below. Avoid freeze-thaw cycles. |
| Storage Buffer | Azide free phosphate buffered saline (PBS), preserved by filter sterilization, approx. pH 7.4 |
