| Product Name | CXCR2 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal antibody [7J40] to CXCR2The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q3 |
| Immunogen | Human recombinant CXCR2 |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG2 |
| Clone Number | 7J40 |
| Host Species | Mouse |
| Tested Applications | FACSIHC-FNeut |
| IHC (frozen)(1:20-100)|FC(1:50-200)|Neutralization of CXCR2 bioactivity: |
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| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | CD182 IL8RB CMKAR2 IL8RA IL8R2 chemokine (C-X-C motif) receptor 2 CDw128b |
|---|---|
| Target | CXCR2 |
| Tissue Specificity | This antibody was selected for its ability to detect human CXCR2 |
| Application Notes | IHC (frozen)(1:20-100)|FC(1:50-200)|Neutralization of CXCR2 bioactivity: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | PBS |
