| Product Name | Cyclin D1 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal antibody [CD1.1] to Cyclin D1The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq, Jul 2008] |
| Immunogen | Human Cyclin D1 |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | CD1.1 |
| Host Species | Mouse |
| Tested Applications | ELISAFACSIHCIHC-FIHC-PIPWB |
| Western Blotting: Max Dilution 1/500, Optimal dilution / concentration should be determined by the end user.: |
|
| Species Reactivity | HumanRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | cyclin D1 PRAD1 CCND1 D11S287E BCL1 U21B31 |
|---|---|
| Target | Cyclin D1 |
| Tissue Specificity | This antibody recognizes cyclin D1. |
| Application Notes | Western Blotting: Max Dilution 1/500, Optimal dilution / concentration should be determined by the end user.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4°C or at -20°C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. |
| Storage Buffer | Phosphate buffered saline containing 0.09% Sodium Azide |
