| Product Name | DAG1 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal antibody [6C1 (4G2)] to DystroglycanDystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants all encoding the same protein.[provided by RefSeq, Apr 2010] |
| Immunogen | A synthetic peptide corresponding to amino acids 572-604 of human cranin (dystroglycan). |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgM |
| Clone Number | 6C1 (4G2) |
| Host Species | Mouse |
| Tested Applications | ELISAIHC-F |
| Immunohistology - Frozen: 1/1 - 1/50 Optimal dilution / concentration should be determined by the end user.: |
|
| Species Reactivity | HumanMouseChickenRatSheepXenopus |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | MDDGC7 MDDGC9 AGRNR 156DAG DAG1 DAG A3A |
|---|---|
| Target | Cranin |
| Tissue Specificity | This antibody recognizes an extracellular region close to the C terminal end of the alpha subunit of human cranin, also known as dystroglycan. |
| Application Notes | Immunohistology - Frozen: 1/1 - 1/50 Optimal dilution / concentration should be determined by the end user.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at -20°C only. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
