| Product Name | DcR3 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal [37A565] to DcR3Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. Several novel members in the TNFR family including DR3, DR4, DR5, and DR6 were recently discovered and function as cell death receptors. Two decoy receptors, DcR1 and DcR2, were recently identified to compete with DR4 and DR5 for their ligand TRAIL binding. A novel decoy receptor was more recently discovered and designated DcR3 and TR6, respectively. Unlike DcR1and DcR2, DcR3 is a soluble rather than a membraneassociated molecule. DcR3 binds to FasL and LIGHT andinhibits FasL and LIGHT induced apoptosis. DcR3 transcript is expressed in a number of lung and coloncarcinomas and in some normal tissues. |
| Immunogen | Full-length protein corresponding to human DcR3. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | 37A565 |
| Host Species | Mouse |
| Tested Applications | WB |
| WB: Use at a concentration of 1 - 2 μg/ml. Detects a band of approximately 34 kDa. For optimal results, primary antibody incubations should be performed at room temperature. Optimal dilutions/concentrations should be determined by the end user.: |
|
| Species Reactivity | Human |
| Concentration | 0.5mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | M68 O95407 TR6 8771 DJ583P15.1.1 TNFRSF6B DCR3 603361 |
|---|---|
| Target | DcR3 |
| Cellular Localization | Secreted |
| Positive Control | Jurkat whole-cell extract |
|---|---|
| Application Notes | WB: Use at a concentration of 1 - 2 μg/ml. Detects a band of approximately 34 kDa. For optimal results, primary antibody incubations should be performed at room temperature. Optimal dilutions/concentrations should be determined by the end user.: |
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| Storage Buffer | Preservative: 0.02% Sodium Azide; Constituents: PBS |
