| Product Name | Desmoglein 3 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal [3G133] to Desmoglein 3Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris. |
| Immunogen | Recombinant fragment (Human Desmoglein 3 extracellular domain). |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | 3G133 |
| Host Species | Mouse |
| Tested Applications | ICC/IFIHC-PIPWB |
| For IF: Use at an assay dependent dilution. For IHC-P: Use at a concentration of 20-50 μg/ml. For IP: Use at a concentration of 5-10 μg/ml. For WB (ECL): Use at a concentration of 1-3 μg/ml. Optimal dilutions/cocentrations should be determined by the researcher.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Synonyms | DKFZp686P23184 169615 Desmoglein 3 CDHF6 P32926 PVA 1830 DSG3 Desmoglein3 |
|---|---|
| Target | Desmoglein 3 |
| Tissue Specificity | Reacts specifically with human Desmoglein 3 protein. Does not crossreact with Desmoglein 1 or Desmoglein 2. |
| Cellular Localization | Type I membrane protein |
| Positive Control | A431 cells |
|---|---|
| Application Notes | For IF: Use at an assay dependent dilution. For IHC-P: Use at a concentration of 20-50 μg/ml. For IP: Use at a concentration of 5-10 μg/ml. For WB (ECL): Use at a concentration of 1-3 μg/ml. Optimal dilutions/cocentrations should be determined by the researcher.: |
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Store at 4ºC short term. For extended storage add 50% glycerol, aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| Storage Buffer | Phosphate-buffered saline, pH 7.4, containing 0.1% sodium azide |
