Application
Detection of DR6 transiently transfected into HeLa cells (green) using anti-DR6 antibody . Cell nuclei visualized by DAPI (blue).Application
Flow cytometry analysis of cell surface expression of DR6 in 6 different cell lines using purified anti-DR6 antibody . Detection by Goat anti-mouse IgG1: PE.| Product Name | DR6 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal [DR - 6 - 04 - EC] to DR6Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. Several novel death receptors including DR3, DR4, and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor 6. Like TNFR1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-kB and JNK. DR6 is widely expressed inhuman tissues and cell lines. The ligand for DR6 hasnot been identified. |
| Immunogen | Fusion protein, corresponding to extracellular amino acids 42-335 of Human DR6, linked to the Fc portion of human IgG1. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | FACSICC/IFIP |
| FACS: Use at an assay dependent dilution. IP: Use at an assay dependent dilution. Antibody immunoprecipitates overexpressed DR6 from DR6-transfected HEK/293 cells. Optimal dilutions/concentrations should be determined by the end user.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Purification | Protein A |
| Gene Synonyms | BM-018 27242 O75509 605732 TNFRSF21 MGC31965 BM018 DR6 BM 018 |
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Application
Detection of DR6 transiently transfected into HeLa cells (green) using anti-DR6 antibody . Cell nuclei visualized by DAPI (blue).
Application
Flow cytometry analysis of cell surface expression of DR6 in 6 different cell lines using purified anti-DR6 antibody . Detection by Goat anti-mouse IgG1: PE.| Application Notes | FACS: Use at an assay dependent dilution. IP: Use at an assay dependent dilution. Antibody immunoprecipitates overexpressed DR6 from DR6-transfected HEK/293 cells. Optimal dilutions/concentrations should be determined by the end user.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| Storage Buffer | Phosphate buffered saline pH 7.4 containing 15mM sodium azide |
